Patch-repetition correlation length in glassy systems

We obtain the patch-repetition entropy Sigma within the Random First Order Transition theory (RFOT) and for the square plaquette system, a model related to the dynamical facilitation theory of glassy dynamics. We find that in both cases the entropy of patches of linear size l, Sigma(l), scales as s_c l^d+A l^{d-1} down to length-scales of the order of one, where A is a positive constant, s_c is the configurational entropy density and d the spatial dimension. In consequence, the only meaningful length that can be defined from patch-repetition is the cross-over length xi=A/s_c. We relate xi to the typical length-scales already discussed in the literature and show that it is always of the order of the largest static length. Our results provide new insights, which are particularly relevant for RFOT theory, on the possible real space structure of super-cooled liquids. They suggest that this structure differs from a mosaic of different patches having roughly the same size.Comment: 6 page

Opinion dynamics with emergent collective memory: A society shaped by its own past

In order to understand the development of common orientation of opinions in the modern world we propose a model of a society described as a large collection of agents that exchange their expressed opinions under the influence of their mutual interactions and external events. In particular we introduce an interaction bias which results in the emergence of a collective memory such that the society is able to store and recall information coming from several external signals. Our model shows how the inner structure of the society and its future reactions are shaped by its own history. We provide an analytical explanation of such mechanism and we study the features of external influences with higher impact on the society. We show the emergent similarity between the reaction of a society modelled in this way and the Hopfield-like mechanism of information retrieval in Neural Networks

An experimental study of the behaviour of two rockfills accounting for the effects of degree of saturation

Rockfill dams have become more and more recognized for their safety, economy and adaptability to widely varying site conditions. As a contribution to the understanding of the main factors affecting the rockfill behaviour, the paper reports and discusses experimental data on several aspects relevant to the interpretation and analysis of their in-situ response. The experimental programme involved three series of oedometric tests on specimens of two different gravels having the same grading, reconstituted at the same initial relative density. Experimental observations on rockfills compressibility are presented and discussed: attention is paid to the role of degree of saturation (Sr) through the analysis of "driest", "fully saturated"conditions, and the transition from one to the other. Grain crushing tests on dry and saturated soil particles are also reported. Grain size distributions of the specimens, both after compaction and after the oedometer tests, are compared in the paper. The results show that the effect of Sr cannot be overlooked in the mechanical characterization of the material, especially in rockfill/stress conditions prone to crushin

Pharmacological Findings on the Biochemical Bases of Memory Processes: A General View

We have advanced considerably in the past 2 to 3 years in understanding the molecular mechanisms of consolidation, retrieval, and extinction of memories, particularly of fear memory. This advance was mainly due to pharmacological studies in many laboratories using localized brain injections of molecularly specific substances. One area in which significant advances have been made is in understanding that many different brain structures are involved in different memories, and that often several brain regions are involved in processing the same memory. These regions can cooperate or compete with each other, depending on circumstances that are beginning to be identified quite clearly. Another aspect in which major advances were made was retrieval and post-retrieval events, especially extinction, pointing to new therapeutic approaches to fearmotivated mental disorders

Towards an Achievable Performance for the Loop Nests

Numerous code optimization techniques, including loop nest optimizations, have been developed over the last four decades. Loop optimization techniques transform loop nests to improve the performance of the code on a target architecture, including exposing parallelism. Finding and evaluating an optimal, semantic-preserving sequence of transformations is a complex problem. The sequence is guided using heuristics and/or analytical models and there is no way of knowing how close it gets to optimal performance or if there is any headroom for improvement. This paper makes two contributions. First, it uses a comparative analysis of loop optimizations/transformations across multiple compilers to determine how much headroom may exist for each compiler. And second, it presents an approach to characterize the loop nests based on their hardware performance counter values and a Machine Learning approach that predicts which compiler will generate the fastest code for a loop nest. The prediction is made for both auto-vectorized, serial compilation and for auto-parallelization. The results show that the headroom for state-of-the-art compilers ranges from 1.10x to 1.42x for the serial code and from 1.30x to 1.71x for the auto-parallelized code. These results are based on the Machine Learning predictions.Comment: Accepted at the 31st International Workshop on Languages and Compilers for Parallel Computing (LCPC 2018

On the convergence of cluster expansions for polymer gases

We compare the different convergence criteria available for cluster expansions of polymer gases subjected to hard-core exclusions, with emphasis on polymers defined as finite subsets of a countable set (e.g. contour expansions and more generally high- and low-temperature expansions). In order of increasing strength, these criteria are: (i) Dobrushin criterion, obtained by a simple inductive argument; (ii) Gruber-Kunz criterion obtained through the use of Kirkwood-Salzburg equations, and (iii) a criterion obtained by two of us via a direct combinatorial handling of the terms of the expansion. We show that for subset polymers our sharper criterion can be proven both by a suitable adaptation of Dobrushin inductive argument and by an alternative --in fact, more elementary-- handling of the Kirkwood-Salzburg equations. In addition we show that for general abstract polymers this alternative treatment leads to the same convergence region as the inductive Dobrushin argument and, furthermore, to a systematic way to improve bounds on correlations

Cluster expansion for abstract polymer models. New bounds from an old approach

We revisit the classical approach to cluster expansions, based on tree graphs, and establish a new convergence condition that improves those by Kotecky-Preiss and Dobrushin, as we show in some examples. The two ingredients of our approach are: (i) a careful consideration of the Penrose identity for truncated functions, and (ii) the use of iterated transformations to bound tree-graph expansions.Comment: 16 pages. This new version, written en reponse to the suggestions of the referees, includes more detailed introductory sections, a proof of the generalized Penrose identity and some additional results that follow from our treatmen

Abstract polymer models with general pair interactions

A convergence criterion of cluster expansion is presented in the case of an abstract polymer system with general pair interactions (i.e. not necessarily hard core or repulsive). As a concrete example, the low temperature disordered phase of the BEG model with infinite range interactions, decaying polynomially as $1/r^{d+\lambda}$ with $\lambda>0$, is studied.Comment: 19 pages. Corrected statement for the stability condition (2.3) and modified section 3.1 of the proof of theorem 1 consistently with (2.3). Added a reference and modified a sentence at the end of sec. 2.

Inhibition of interleukin-6-induced matrix metalloproteinase-2 expression and invasive ability of lemon peel polyphenol extract in human primary colon cancer cells

Among matrix metalloproteinases (MMPs), MMP-9/2 are key enzymes involved in the proteolysis of extracellular matrices in the inflammatory process and in cancer. Since MMP-9/2 expression levels, activity, and secretion is up-regulated during inflammation in response to pro-inflammatory cytokines, such as interleukin-6 (IL-6), many efforts have been devoted to identifying factors that could inhibit the IL-6-induced MMP-9/2 expression. Up to now, several reports in-dicated that polyphenols from fruits and vegetables are among the major components of health promotion for their antioxidant properties and also for their anti-inflammatory and anti-cancer agents. Among plant derived polyphenols, lemon (Citrus limon) peel extract (LPE) shows anti-cancer properties in various cancer types. In our previous work, we demonstrated that LPE can reduce IL-6-induced migration/invasiveness and MMP-9/2 up-regulation in some gastric cancer cell lines. This study aims to exploit the anti-cancer properties of LPE using an in vitro system model of inflam-mation, consisting of IL-6-exposed human primary colon cancer cells. We first analyzed the effect of LPE on IL-6-induced cell migration and invasiveness by wound healing and Boyden chamber assay, respectively. The MMP-2 mRNA expression levels and gelatinolytic activity in the cell culture media were determined by q-PCR analysis and gelatin zymography, respectively, and finally, the effects of LPE on IL-6-induced JAK2/STAT3 signaling pathways have been investigated by Western blotting analysis. Our results show that LPE is able to inhibit the IL-6-dependent cell migration and invasiveness associated with the up-regulation of MMP-2 expression levels and that these effects are correlated to the STAT3 phosphorylation in human primary T88 and T93 colon cancer cells

A arte de esquecer

IN THE LAST twenty years we have witnessed an extraordinary progress in our knowledge about the molecular processes involved in memory acquisition, consolidation and retrieval. However and despite the fact that memory formation is indissolubly intermingled with memory forgetting, we know very little about this phenomenon. What are the causes of forgetting? How do we forget? Is there an active forgetting process or this phenomenon is simply due to interference by other memories or to decay due to the passage of time? In this review, we comment briefly on this subject and others related to memory persistence. In particular, we analyze whether expression of the mnemonic trace has any effect on its perdurability.NOS ÚLTIMOS vinte anos vimos presenciando um notável avanço no que diz respeito ao conhecimento acerca dos mecanismos moleculares envolvidos na aquisição, consolidação e expressão de memórias. Porém, e apesar de que resulte óbvio que a nossa capacidade de formar novas memórias está intimamente ligada a sua perda, muito pouco se sabe a respeito do esquecimento. Quais as causas do esquecimento? Como esquecemos? Existe um processo ativo de esquecimento ou esse fenômeno é simplesmente decorrente da interferência de outras memórias ou da passagem do tempo? Neste artigo, comentamos brevemente este e outros temas relacionados com a persistência da memória, em particular, analisamos a influência que a utilização do traço mnemônico tem na sua perdurabilidade